Job Description
Overview We are currently searching for a skilled professional to join a well-known client’s team as a Research Associate in South San Francisco, California. The Research Associate role will provide technical support for a cross-functional effort to deeply characterize cellular response towards various small molecules and biologics across human intestinal model systems to enhance clinical intestinal risk predictions. Their work will have a direct impact on the organization and the larger clinical industry, making this an amazing career opportunity.
Responsibilities - Provide technical assistance in developing and implementing in vitro assays using intestinal organoid-derived models
- Collaborate with cross-functional teams to characterize in vitro response to various small molecules and biologics, including but not limited to cell viability assays, permeability assays high high-throughput imaging and single-cell RNA-sequencing.
- Independently execute toxicity and image-based assays.
- Partner with culture automation teams to establish workflows for high-throughput screens.
- Analyze, interpret, and present data to collaborators and stakeholders as appropriate, with clear verbal and written communication.
- Maintain detailed electronic documentation consistent with departmental SOPs, covering execution and results, and contribute to final reports as appropriate.
- This role will involve sitting and standing for extended periods, performing some repetitive tasks, and working with potentially hazardous materials, including, but not limited to, chemotherapeutics, biological hazards, and human primary cells.
Experience 4+ years of wet lab-based experience in academic, biotech/pharmaceutical, or research organizations.
EDUCATION
Minimum of Bachelor’s Degree in biology, bioengineering, biomedical engineering, pharmacology/toxicology, or a related field
To Be a Best-fit Your Strengths Must Include - Significant laboratory-based expertise with tissue culture is required, particularly with primary tissue-derived cell lines or iPSCs. Experience with 3D organoid or organoid-derived technologies (monolayers, microphysiological systems/chips, etc) is highly desirable.
- Proficient in molecular biology/quantitative end point assays such as antibody (ELISA) and cell-based viability assays (LDH, CellTiter-Glo) at scale (96-384 well formats).
- Experience with routine imaging and image-based analysis is preferred, including immunofluorescence, confocal microscopy, and high-content imaging.
- Experience developing, qualifying, and applying CIVMs in a biotech/pharmaceutical setting is highly desirable.
About Advanced Clinical Advanced Clinical is an award-winning clinical development organization that provides global services including CRO, Functional Support, Quality & Validation, Patient Recruitment and Retention, and Strategic Talent Acquisition solutions for pharmaceutical, biopharmaceutical, biotechnology, and medical device organizations. Our mission is to deliver a truly better clinical experience for our clients and candidates. To learn more about Advanced Clinical which has been named to Chicago Tribune’s Top Workplaces, Chicago’s Best and Brightest Companies, and Best of Staffing Talent & Client, visit
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